The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 03, 2024

Filed:

Aug. 22, 2017
Applicant:

Cttq-akeso (Shanghai) Biomed. Tech. Co., Ltd., Shanghai, CN;

Inventors:

Baiyong Li, Guangdong, CN;

Yu Xia, Guangdong, CN;

Zhongmin Maxwell Wang, Guangdong, CN;

Peng Zhang, Guangdong, CN;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); A61P 35/02 (2006.01); C07K 16/28 (2006.01); G01N 33/577 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
A61K 39/395 (2013.01); A61P 35/02 (2018.01); C07K 16/28 (2013.01); G01N 33/577 (2013.01); G01N 33/68 (2013.01);
Abstract

An anti-PDl (programmed cell death 1) monoclonal antibody or an antigen-binding fragment thereof, a pharmaceutical composition thereof and use thereof. The heavy chain variable region of the monoclonal antibody comprises CDRs (complementary determining region) of amino acid sequences as shown in SEQ ID NO:9-11; and/or the light chain variable region of the monoclonal antibody comprises CDRs of amino acid sequences as shown in SEQ ID NO: 12-14. The monoclonal antibody can bind to PDl specifically, relieve immunosuppression of PDl on an organism specifically and activate T lymphocytes.


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