The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 03, 2024

Filed:

Mar. 02, 2023
Applicant:

Yisheng Biopharma (Singapore) Pte. Ltd., Singapore, SG;

Inventors:

Yi Zhang, Singapore, SG;

Yuhe Yan, Singapore, SG;

Xu Zhang, Singapore, SG;

Thomas Anthony Coton, Singapore, SG;

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/145 (2006.01); A61K 39/00 (2006.01); A61K 39/12 (2006.01); C12N 5/00 (2006.01); C12N 7/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/145 (2013.01); C12N 7/00 (2013.01); C12N 2760/16152 (2013.01);
Abstract

A method for adapting an influenza virus to Vero cells is provided. The method comprises infecting Vero cells with the influenza virus, cultivating the infected Vero cells, harvesting influenza viruses of each passage, wherein infectious dose of the influenza viruses of one passage is greater than or equal to infectious dose of the influenza viruses of a previous passage. The present disclosure also relates to a composition. Said composition comprises polyriboinosinic acid-polyribocytidylic acid, at least one antibiotic or polyamide compound, at least one positive ion, influenza viruses and/or influenza antigens, wherein said influenza viruses and/or influenza antigens are acquired from Vero cell adapted influenza viruses.


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