The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 03, 2024
Filed:
Oct. 19, 2022
Applicant:
Affimed Gmbh, Heidelberg, DE;
Inventors:
Michael Kluge, Heidelberg, DE;
Michael Tesar, Heidelberg, DE;
Ivica Fucek, Heidelberg, DE;
Kristina Ellwanger, Heidelberg, DE;
Uwe Reusch, Heidelberg, DE;
Michael Damrat, Heidelberg, DE;
Erich Rajkovic, Heidelberg, DE;
Martin Treder, Heidelberg, DE;
Assignee:
AFFIMED GMBH, Heidelberg, DE;
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 47/65 (2017.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/001104 (2018.08); A61K 39/001129 (2018.08); A61K 47/65 (2017.08); A61P 35/00 (2018.01);
Abstract
Described are tetravalent, bispecific EGFR/CD16A antigen-binding proteins for engaging NK-cells towards EGFR-positive cells. EGFR/CD16A antigen-binding proteins with different pharmacokinetic (PK) properties are described. Further described is the use of bispecific EGFR/CD16A antigen-binding proteins for the treatment of an EGFR-positive malignancy, such as EGFR-positive tumors.