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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12076346 B1

PDFFull Text
Date of Patent:
Sep. 03, 2024

Filed:

Feb. 09, 2023

Hla-f-modified cells and methods

Applicant:

Applied Stemcell, Inc., Milpitas, CA (US);

Inventors:

Ruby Yanru Tsai, San Jose, CA (US);

Alfonso Farruggio, Stanford, CA (US);

Xiuling Chi, San Jose, CA (US);

Kai Wang, Newark, CA (US);

Assignee:

APPLIED STEMCELL, INC., Milpitas, CA (US);

Attorneys:

Jun He Law Offices P.C

James J. Zhu

Primary Examiner:

Anoop K Singh

Assistant Examiner:

David A Montanari

Int. Cl.
CPC ...
A61K 35/17 (2015.01); C07K 14/705 (2006.01); C07K 14/74 (2006.01); C07K 16/28 (2006.01); C12N 5/0735 (2010.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
A61K 35/17 (2013.01); C07K 14/70539 (2013.01); C07K 14/70575 (2013.01); C07K 16/2896 (2013.01); C12N 5/0606 (2013.01); G01N 33/5014 (2013.01);
Abstract

The present disclosure provides compositions and methods for cell transplantation therapy based on forced expression of an exogenous HLA-F protein in donor cells to be transplanted into a subject. In some embodiments, the donor cells express an exogenous chimeric HLA-F protein comprising an extracellular region comprising an HLA-F alpha 1 domain, an HLA alpha 2 domain, an HLA-F alpha 3 domain, a linker and a β2m protein.

Find Patent Forward Citations

Tsai, Ruby. (2024). Hla-f-modified cells and methods (U.S. Patent No. 12076346). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12076346

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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