The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 27, 2024
Filed:
Feb. 07, 2019
Centre National DE LA Recherche Scientifique, Paris, FR;
Universite DE Montpellier, Montpellier, FR;
Centre Hospitalier Universitaire DE Montpellier, Montpellier, FR;
Alboukadel Kassambara, Marvejols, FR;
Jérôme Moreaux, Montpellier, FR;
Wafa Hassen, Montpellier, FR;
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Paris, FR;
UNIVERSITE DE MONTPELLIER, Montpellier, FR;
CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER, Montpellier, FR;
Abstract
Disclosed is a method for in vitro predicting the outcome of an individual having a multiple myeloma, including: —a) measuring the expression level of at least 2 genes encoding a ROS detoxifying (AOX) protein selected in a group including AKR1 B1, ARNT, CAT, CBR1, DHCR24, EGLN1, GLRX2, HIF1A, MGST1, MSRB1, PRDX6, SLC7A11, SOD1, SRXN1, TALDO1 and TXN and/or the expression level of at least 2 genes encoding ROS producing (ROS) protein selected in a group including CYBA, CYB5A, CYC1, NCF1B, NCF1C, NCF4, NDUFA12, NDUFS2, NDUFS8, SHC1 and UQCR10, in a biological sample obtained from the individual; —b) calculating an AOX score value and/or a ROS score value from the respective expression level(s) obtained at step a); —c) classifying the individual as having a good prognosis status or a bad prognosis status, by comparing the score value obtained at step b) with a reference score value.