The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 27, 2024

Filed:

Sep. 17, 2021
Applicant:

The United States of America, As Represented BY the Secretary of Agriculture, Washington, DC (US);

Inventors:

Robert E Briggs, Boone, IA (US);

Fred M Tatum, Nevada, IA (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 9/16 (2006.01); A61K 39/102 (2006.01); C12N 9/04 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/0006 (2013.01); A61K 39/102 (2013.01); C12N 9/16 (2013.01); C12Y 101/01022 (2013.01); C12Y 301/03029 (2013.01); A61K 2039/522 (2013.01); A61K 2039/552 (2013.01);
Abstract

The present invention provides novel attenuatedstrains that may be used, in live or killed form, to formulate vaccines that are highly protective againstinfection in bovines, other mammals, and in birds. The present invention also identifies the combination of nanP and hyaC gene mutations as key to the provision of such vaccines. When appropriately formulated, antigenic material of numerous other bovine pathogens may be combined with the live attenuatedstrains, to make effective combination vaccines.


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