The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 27, 2024
Filed:
Mar. 21, 2023
Novo Nordisk Health Care Ag, Zurich, CH;
Anna Ericsson, Shrewsbury, MA (US);
Neal Green, Newton, MA (US);
Gary Gustafson, Ridgefield, CT (US);
Bingsong Han, Westwood, MA (US);
David R. Lancia, Jr., Boston, MA (US);
Lorna Mitchell, West Beach, AU;
David Richard, Littleton, MA (US);
Tatiana Shelekhin, Ridgefield, CT (US);
Chase C. Smith, Rutland, MA (US);
Zhongguo Wang, Lexington, MA (US);
Xiaozhang Zheng, Lexington, MA (US);
Novo Nordisk Health Care AG, Zurich, CH;
Abstract
The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.