The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 27, 2024
Filed:
Sep. 12, 2019
Genentech, Inc., South San Francisco, CA (US);
Marie-Gabrielle Braun, San Francisco, CA (US);
Cuong Q. Ly, Burlingame, CA (US);
Georgette Castanedo, Redwood City, CA (US);
Paul Gibbons, San Francisco, CA (US);
Wendy Lee, San Ramon, CA (US);
Joachim Rudolph, Burlingame, CA (US);
Nicole Alice Blaquiere, Oakland, CA (US);
Jacob Bradley Schwarz, San Ramon, CA (US);
Ramsay Beveridge, Pointe-Claire, CA;
Jean-Philippe Leclerc, Laval, CA;
Alexandre Lemire, Blainville, CA;
Leo Fu, Shanghai, CN;
Genentech, Inc., South San Francisco, CA (US);
Abstract
Described herein are phenoxy-pyridyl-pyrimidine compounds with inositol requiring enzyme 1 (IRE1) modulation activity or function having the Formula I structure or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such IRE1 modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.