The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 27, 2024
Filed:
Feb. 25, 2019
Applicant:
Virginia Commonwealth University, Richmond, VA (US);
Inventors:
Frank B. Gupton, Richmond, VA (US);
Saeed Ahmad, Chesterfield, VA (US);
Hari P. R. Gunuru, Henrico, VA (US);
Nakul S. Telang, Richmond, VA (US);
Assignee:
Virginia Commonwealth University, Richmond, VA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 215/46 (2006.01); B01J 8/04 (2006.01); B01J 19/00 (2006.01); B01J 19/18 (2006.01); B01J 19/24 (2006.01);
U.S. Cl.
CPC ...
C07D 215/46 (2013.01); B01J 8/0492 (2013.01); B01J 19/0013 (2013.01); B01J 19/0066 (2013.01); B01J 19/1862 (2013.01); B01J 19/245 (2013.01); B01J 2219/00033 (2013.01); B01J 2219/0004 (2013.01);
Abstract
Cost effective, semi-continuous flow methods and systems for synthesizing the antimalarial drug hydroxychloroquine (HCQ) in high yield are provided. The synthesis method that uses simple, inexpensive reagents to obtain the crucial intermediate 5-(ethyl(2-hydroxyethyl)-amino)pentan-2-one, vertical-integration of the starting material 5-iodopentan-2-one and the integration of continuous stirred tank reactors.