The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 27, 2024
Filed:
Jun. 28, 2022
Applicant:
GE Healthcare As, Oslo, NO;
Inventors:
Mikkel Jacob Thaning, Oslo, NO;
Andreas Richard Meijer, Oslo, NO;
Assignee:
GE HEALTHCARE AS, Oslo, NO;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 49/10 (2006.01); A61K 9/00 (2006.01); A61K 31/28 (2006.01); C07D 257/00 (2006.01);
U.S. Cl.
CPC ...
A61K 49/108 (2013.01); A61K 9/0019 (2013.01); A61K 31/28 (2013.01); A61K 49/106 (2013.01); C07D 257/00 (2013.01);
Abstract
The present invention relates to a method of removal of metal ion impurities, such as calcium, from lanthanide metal complexes of macrocyclic chelators. The method uses a scavenger resin to remove metal ions, displaced from chelator, by an excess of lanthanide ions. Also provided is a method of preparation of MRI contrast agents, from the purified lanthanide metal complex, by the addition of a defined excess chelator.