The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 27, 2024
Filed:
Jun. 24, 2019
Applicant:
The Board of Regents of the University of Texas System, Austin, TX (US);
Inventors:
Jerry Shay, Dallas, TX (US);
Ilgen Mender, Dallas, TX (US);
Kimberly Batten, Dallas, TX (US);
Sergei Gryaznov, Chicago, IL (US);
Assignee:
The Board of Regents of The University of Texas System, Austin, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/7076 (2006.01); A61K 9/00 (2006.01); A61K 31/7105 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7076 (2013.01); A61K 9/0019 (2013.01); A61K 31/7105 (2013.01); A61K 45/06 (2013.01);
Abstract
The described invention is directed toward pharmaceutical compositions and methods of using 6-mercaptopurine ribosides and analogues thereof for the treatment of cancer and other hyperproliferative diseases. The described compounds can be converted into telomere substrates in vivo and can be recognized by telomerase for incorporation into telomeres of telomerase active cells, leading to induction of cell death of the telomerase active cells.