The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 27, 2024
Filed:
Nov. 10, 2022
Applicant:
The Trustees of Columbia University IN the City of New York, New York, NY (US);
Inventors:
Carrie J. Shawber, Washington, NJ (US);
June K. Wu, New York, NY (US);
Ajit Muley, San Mateo, CA (US);
Assignee:
The Trustees of Columbia University in the City of New York, New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/145 (2006.01); A61K 31/407 (2006.01); A61K 31/501 (2006.01); A61K 31/69 (2006.01); A61K 38/06 (2006.01); A61K 38/07 (2006.01); A61P 9/14 (2006.01);
U.S. Cl.
CPC ...
A61K 31/69 (2013.01); A61K 31/145 (2013.01); A61K 31/407 (2013.01); A61K 31/501 (2013.01); A61K 38/06 (2013.01); A61K 38/07 (2013.01); A61P 9/14 (2018.01);
Abstract
Provided herein are methods and compositions for treating and preventing vascular malformations including lymphatic, venous, capillary, arteriovenous, and combinations thereof. Methods of treatment and prevention include the administration of proteasome inhibitors, omipalisib, disulfiram, and agents which target genes in the PI3K/AKT/mTOR or RAS/RAF/MAPK pathways, including but not limited to Pik3ca, Pik3r3, Tsc2, Rasa1, Map2k2, and Glmn.