The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 20, 2024

Filed:

Jan. 07, 2021
Applicant:

Lawrence Livermore National Security, Llc, Livermore, CA (US);

Inventors:

Fang Qian, Santa Cruz, CA (US);

Chao Huang, San Jose, CA (US);

Anna Nikolaevna Ivanovskaya, Mountain View, CA (US);

Kris Kulp, Livermore, CA (US);

Elizabeth K. Wheeler, Livermore, CA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/483 (2006.01); C12M 1/34 (2006.01); C12M 1/42 (2006.01); C12M 3/00 (2006.01);
U.S. Cl.
CPC ...
G01N 33/4836 (2013.01); C12M 21/08 (2013.01); C12M 35/02 (2013.01); C12M 41/46 (2013.01);
Abstract

A method includes simultaneously measuring electrophysiological responses and contractility responses of a plurality of cells forming a tissue culture using a system comprising a sensor array configured to simultaneously measure the electrophysiological responses and the contractility responses of the plurality of cells forming the tissue culture. Fabrication techniques for making such systems include: forming a sensor array comprising an interpenetrating arrangement of IDEs and electrodes of a MEA in or on a substrate surface; forming a plurality of contacts for interfacing the system with one or more external devices in or on the substrate surface; and forming leads between the plurality of contacts and the sensor array.


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