The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 20, 2024

Filed:

Aug. 17, 2020
Applicant:

Utah State University, North Logan, UT (US);

Inventors:

Randolph V. Lewis, Nibley, UT (US);

Justin A. Jones, Nibley, UT (US);

Xiaoli Zhang, Nibley, UT (US);

Assignee:

UTAH STATE UNIVERSITY, North Logan, UT (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/85 (2006.01); C07K 14/46 (2006.01); C07K 14/78 (2006.01);
U.S. Cl.
CPC ...
C12N 15/8509 (2013.01); C07K 14/461 (2013.01); C07K 14/78 (2013.01); A01K 2217/07 (2013.01); A01K 2227/706 (2013.01);
Abstract

Transgenic silkworms stably expressing hagfish thread keratin genes or composite silkworm/hagfish thread keratin genes are disclosed. The exogenous hagfish thread keratin genes are stably integrated into a defined site of the fibroin heavy chain intron or a fibroin light chain intron of silkworms. Synthetic hagfish thread keratin proteins and composite hagfish thread keratin-silkworm genes and proteins are provided. The expression of exogenous hagfish thread keratin genes is driven by the endogenous fibroin heavy chain promoter, improving the genetic stability of transgenic silkworms. The composite silkworm/hagfish thread keratin fibers exhibit exceptional mechanical performance, compared to normal silkworm silk fibers and other transgenic silkworm fibers.


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Lewis, Randolph. (2024). Transgenic silkworms expressing hagfish thread keratin (U.S. Patent No. 12065660). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12065660

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