The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 20, 2024
Filed:
Jan. 07, 2022
Bristol-myers Squibb Company, Princeton, NJ (US);
Janssen Pharmaceuticals, Inc., Titusville, NJ (US);
Joseph M. Luettgen, Princeton, NJ (US);
Lumelle Schneeweis, Princeton, NJ (US);
Ginger Chao Rakestraw, Cambridge, MA (US);
Christina Terragni, Cambridge, MA (US);
Andrew Karl Dilger, Princeton, NJ (US);
Jason Robert Pinckney, Cambridge, MA (US);
Steven Sheriff, Princeton, NJ (US);
Kevin Kish, Princeton, NJ (US);
Yongmi An, Princeton, NJ (US);
William R. Ewing, Princeton, NJ (US);
Stanley Richard Krystek, Jr., Ringoes, NJ (US);
Aaron Paul Yamniuk, Vancouver, CA;
Bristol-Myers Squibb Company, Princeton, NJ (US);
Abstract
The present invention provides novel antigen binding peptides, such as an antibody or antibody fragment, that specifically bind to selective FXIa inhibitors and/or dual inhibitors of FXIa, and plasma kallikrein. The present invention further relates to methods of reducing the antithrombotic effect of FXIa inhibitors by administering to a subject a pharmaceutically effective dose of the antigen binding peptides provided herein. In addition, the present invention provides detection reagents and methods for detecting the level of the inhibitors of FXIa in a biological sample.