The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 20, 2024
Filed:
Feb. 24, 2022
Synesis Llc, Wisconsin Rapids, WI (US);
Jess D. Reed, Verona, WI (US);
Daniel Alfredo Esquivel-Alvarado, Wisconsin Rapids, WI (US);
Emilia Alfaro-Viquez, Wisconsin Rapids, WI (US);
Christian G. Krueger, Cambridge, WI (US);
Synesis LLC, Wisconsin Rapids, WI (US);
Abstract
Proanthocyanidin-cinnamaldehydes pyrylium products (FP) were synthesized by the condensation reaction of proanthocyanidins (PAC) with various cinnamaldehydes. Synthesized FP exhibited fluorescence at higher excitation and emission wavelengths than PAC. FP were evaluated for their ability to agglutinate extra-intestinal pathogenic(ExPEC). Results showed that FP were significantly more bioactive (p-value<0.05) for agglutinating ExPEC compared to PAC. Scanning electron microscopy indicates that FP interacts with ExPEC surface structures and suggests that FP have higher affinity with the fimbriae-like structures on the surface of ExPEC in comparison to PAC. In addition, fluorescent microscopy performed on in vitro and in vivo agglutination assays show that FP entrap ExPEC in a web-like network, thus demonstrating agglutination of ExPEC. Fluorescent proanthocyanidins offer a new approach to visualize bacterial infections and to treat such infections.