The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 20, 2024
Filed:
Mar. 15, 2022
Massachusetts Institute of Technology, Cambridge, MA (US);
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Carlo Giovanni Traverso, Newton, MA (US);
Alex G. Abramson, St. Louis, MO (US);
Ester Caffarel Salvador, Cambridge, MA (US);
Niclas Roxhed, Bromma, SE;
Minsoo Khang, Boston, MA (US);
Taylor Bensel, Walpole, MA (US);
Robert S. Langer, Newton, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Abstract
Components with relatively high loading of active pharmaceutical ingredients (e.g., drugs), are generally provided. In some embodiments, the component (e.g., a tissue interfacing component) comprises a solid therapeutic agent (e.g., a solid API) and a supporting material (e.g., a binder such as a polymer) such that the solid therapeutic agent is present in the component in an amount of greater than or equal to 10 wt % versus the total weight of the tissue interfacing component. Such tissue-interfacing components may be useful for delivery of API doses e.g., to a subject. Advantageously, in some embodiments, the reduction of volume required to deliver the required API dose as compared to a liquid formulation permits the creation of solid needle delivery systems for a wide variety of drugs in a variety of places/tissues (e.g., tongue, GI mucosal tissue, skin) and/or reduces and/or eliminates the application of an external force in order to inject a drug solution through the small opening in the needle. In some cases, a physiologically relevant dose may be present in a single tissue interfacing component (e.g., having a relatively high API loading).