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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12064426 B1

PDFFull Text
Date of Patent:
Aug. 20, 2024

Filed:

Jan. 05, 2022

Selective inhibitors of rock1 and rock2 protein kinases and uses thereof

Applicant:

Genosco Inc., Billerica, MA (US);

Inventors:

Wongil Lee, Bedford, MA (US);

William G. Devine, Woburn, MA (US);

R. Bruce Diebold, Waltham, MA (US);

So Young Hwang, Lexington, MA (US);

Yunggeun Choi, Acton, MA (US);

Yan Liu, Boston, MA (US);

Sang-Ae Seung, Lexington, MA (US);

Miyong Yong, Belmont, MA (US);

Sewon Kim, Cambridge, MA (US);

Jaekyoo Lee, North Andover, MA (US);

Jong Sung Koh, Cambridge, MA (US);

Assignee:

GENOSCO Inc., Billerica, MA (US);

Attorneys:

United One Law Group LLC

Kongsik Kim

Jhongwoo Peck

Primary Examiner:

Joseph R Kosack

Assistant Examiner:

Jed A Kucharczk

Int. Cl.
CPC ...
A61K 31/4725 (2006.01); A61K 31/4375 (2006.01); A61K 31/496 (2006.01); A61K 31/517 (2006.01); A61K 31/5377 (2006.01); A61K 31/5386 (2006.01); A61K 31/675 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 403/14 (2006.01); C07D 405/14 (2006.01); C07D 413/04 (2006.01); C07D 413/14 (2006.01); C07D 471/04 (2006.01); C07D 498/08 (2006.01); C07D 513/04 (2006.01); C07F 9/6558 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4725 (2013.01); A61K 31/4375 (2013.01); A61K 31/496 (2013.01); A61K 31/517 (2013.01); A61K 31/5377 (2013.01); A61K 31/5386 (2013.01); A61K 31/675 (2013.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 413/04 (2013.01); C07D 413/14 (2013.01); C07D 471/04 (2013.01); C07D 498/08 (2013.01); C07D 513/04 (2013.01); C07F 9/65583 (2013.01); C07B 2200/05 (2013.01);
Abstract

The present invention relates to novel substituted bicyclic derivatives that can inhibit Rho-kinases and/or Rho-kinase mediated phosphorylation of myosin light chain phosphates, compositions comprising the derivatives, methods for preparing the derivatives, and methods for using the derivatives and/or compositions.

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