The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 20, 2024
Filed:
Sep. 24, 2020
Applicant:
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Inventors:
Lynn Macdonald, Harrison, NY (US);
Andrew J. Murphy, Croton-on-Hudson, NY (US);
Naxin Tu, Pleasantville, NY (US);
Cagan Gurer, Chappaqua, NY (US);
Assignee:
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Primary Examiner:
Int. Cl.
CPC ...
A01K 67/0278 (2024.01); C07K 14/705 (2006.01); C12N 5/0735 (2010.01); C12N 5/0783 (2010.01); C12N 5/10 (2006.01); C12N 15/85 (2006.01); C07K 14/73 (2006.01); C07K 14/74 (2006.01);
U.S. Cl.
CPC ...
A01K 67/0278 (2013.01); C07K 14/70517 (2013.01); C12N 5/0606 (2013.01); C12N 5/0636 (2013.01); C12N 5/10 (2013.01); C12N 15/8509 (2013.01); A01K 2207/15 (2013.01); A01K 2217/072 (2013.01); A01K 2267/03 (2013.01); C07K 14/70514 (2013.01); C07K 14/70539 (2013.01); C07K 2319/00 (2013.01); C12N 2517/02 (2013.01);
Abstract
The invention provides genetically modified non-human animals that express chimeric human/non-human T cell co-receptor polypeptides (e.g., CD4, CD8α, CD8β), as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same.