The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 13, 2024
Filed:
Dec. 30, 2020
Incyte Corporation, Wilmington, DE (US);
Horacio G. Nastri, West Chester, PA (US);
Shaun M. Stewart, Chadds Ford, PA (US);
Juan Carlos Almagro, Cambridge, MA (US);
Jing Zhou, Boxborough, MA (US);
Rebecca A. Buonpane, Wilmington, DE (US);
Hui Wang, Hockessin, DE (US);
Yingnan Chen, Wilmington, DE (US);
Xiaozhao Wang, Mt. Laurel, NJ (US);
Peter Niels Carlsen, Claymont, DE (US);
Yong Li, Newark, DE (US);
Chao Qi, Newark, DE (US);
Liangxing Wu, Wilmington, DE (US);
Wenqing Yao, Chadds Ford, PA (US);
Wenyu Zhu, Media, PA (US);
Taisheng Huang, Wilmington, DE (US);
Incyte Corporation, Wilmington, DE (US);
Abstract
Disclosed are combination therapies comprising administration of a CD73 inhibitor and an adenosine A2A or A2B receptor inhibitor. The disclosed combination therapies are useful in the treatment of diseases related to the activity of adenosine receptors and/or CD73 including, for example, cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases. Anti-CD73 antibodies and A2A/A2B inhibitors are also disclosed.