The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 13, 2024
Filed:
Dec. 20, 2018
Amunix Pharmaceuticals, Inc., Mountain View, CA (US);
Fan Yang, San Jose, CA (US);
Volker Schellenberger, Palo Alto, CA (US);
Vladimir Podust, Castro Valley, CA (US);
Bee-Cheng Sim, Mountain View, CA (US);
Desiree Thayer, Burlingame, CA (US);
John Beaber, Redwood City, CA (US);
AMUNIX PHARMACEUTICALS, INC., South San Francisco, CA (US);
Abstract
The present invention relates to activatable recombinant polypeptide compositions comprising a cleavage release segment. In some instances, the activatable recombinant polypeptide compositions include an XTEN linked to binding moieties by cleavable release segments that, when cleaved, the binding moieties are capable of binding together effector T cells with targeted tumor or cancer cells and effecting cytolysis of the tumor cells or cancer cells. The invention also provides compositions and methods of making and using the cleavable activatable recombinant compositions.