The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 13, 2024
Filed:
Apr. 12, 2021
Bristol-myers Squibb Company, Princeton, NJ (US);
Mark F. Maurer, Seattle, WA (US);
Tseng-hui Timothy Chen, Burlingame, CA (US);
Brigitte Devaux, Palo Alto, CA (US);
Mohan Srinivasan, Cupertino, CA (US);
Susan H. Julien, Seattle, WA (US);
Paul O. Sheppard, Granite Falls, WA (US);
Daniel F. Ardourel, Woodinville, WA (US);
Indrani Chakraborty, Fremont, CA (US);
BRISTOL-MYERS SQUIBB COMPANY, Princeton, NJ (US);
Abstract
The present invention provides antibodies, or antigen binding fragments thereof, that bind to human TIGIT (T cell immunoreceptor with Ig and ITIM domains), as well as uses of these antibodies or fragments in therapeutic applications, such as in the treatment of cancer or chronic viral infection. Such method of treatment include combination therapy with inhibitors of other immunomodulatory receptor interactions, such as the PD-1/PD-L1 interaction. The invention further provides polynucleotides encoding the heavy and/or light chain variable region of the antibodies, expression vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies, cells comprising the vectors, and methods of making the antibodies or fragments by expressing them from the cells.