The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 13, 2024
Filed:
Oct. 16, 2018
Applicant:
Kansas State University Research Foundation, Manhattan, KS (US);
Inventors:
Raymond R. R. Rowland, Manhattan, KS (US);
Ana Stoian, Manhattan, KS (US);
Assignee:
Kansas State University Research Foundation, Manhattan, KS (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/705 (2006.01); A01K 67/027 (2006.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
C07K 14/705 (2013.01); A01K 67/027 (2013.01); C12N 15/85 (2013.01);
Abstract
The present disclosure provides compositions and methods for decreasing permissiveness to infection by PRRSV. The methods involve inserting peptides or oligopeptides into the CD163 SRCR domain 5 to disrupt the protein structure and thereby prevent PRRSV infection. The deletion of the exonregion of PSTII eliminates infection. The replacement of cysteine residues with alanines in SRCR5 as a means to disrupt disulfide bond formation. The final method is the deletion of, or amino acid substitution within the SRCR4-5 interdomain region.