The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 13, 2024
Filed:
Apr. 06, 2021
Applicant:
Pylum Biosciences, Inc., Lewes, DE (US);
Inventors:
Dana Gebhart, San Francisco, CA (US);
Dean Scholl, Burlingame, CA (US);
Assignee:
PYLUM BIOSCIENCES, INC., Lewes, DE (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/195 (2006.01); C12N 15/75 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/195 (2013.01); C12N 15/75 (2013.01); A61K 38/00 (2013.01);
Abstract
The present disclosure relates to the identification, cloning, and expression of a genetic locus within angenome that encodes a phage tail-like bacteriocin (PTLB), termed an enterocin. Also provided are non-natural enterocins, which have been engineered to have altered bactericidal specificity. Nucleic acid molecules encoding natural or non-natural enterocins, vector constructs containing such nucleic acids operably linked to a heterologous promoter, producer cells containing such vectors, the encoded enterocins, as well as methods of making and using such enterocins are described.