The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 13, 2024
Filed:
Apr. 04, 2022
The Institute of Cancer Research: Royal Cancer Hospital, London, GB;
Richard Marais, Manchester, GB;
Caroline Springer, Manchester, GB;
Dan Niculescu-Duvaz, Manchester, GB;
Natalie Miller, Manchester, GB;
Mohammed Aljarah, Manchester, GB;
Alfonso Zambon, Reggio Emilia, IT;
Leo Leung, Manchester, GB;
Deborah Smithen, Manchester, GB;
Michael Brown, Manchester, GB;
Haoran Tang, Manchester, GB;
Abstract
This invention relates to compounds useful as lysyl oxidase (LOX) and lysyl oxidase-like (LOXL) family member (LOXL1, LOXL2, LOXL3, LOXL4) inhibitors. In addition there are contemplated pharmaceutical compositions comprising the compounds and the use of the compounds in the treatment of conditions mediated by LOX and LOXL, for example cancer. In particular a LOX inhibitor such as the present compounds may be for use in the treatment of a cancer associated with EGFR. The present invention also contemplates the identification of biomarkers that predict responsiveness to a LOX inhibitor.