The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 13, 2024

Filed:

Jan. 25, 2022
Applicant:

The General Hospital Corporation, Boston, MA (US);

Inventors:

Conor L. Evans, Boston, MA (US);

Gabriela Apiou, Boston, MA (US);

Alexander J. Nichols, Boston, MA (US);

Emmanouil Rousakis, Boston, MA (US);

Zongxi Li, Boston, MA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/22 (2006.01); A61B 5/00 (2006.01); A61B 5/1455 (2006.01); A61B 90/00 (2016.01); A61K 49/00 (2006.01); A61F 13/00 (2006.01);
U.S. Cl.
CPC ...
A61K 49/0015 (2013.01); A61B 5/14551 (2013.01); A61B 5/14552 (2013.01); A61B 5/14556 (2013.01); A61B 5/443 (2013.01); A61B 5/6833 (2013.01); A61B 90/39 (2016.02); C07D 487/22 (2013.01); A61B 5/0022 (2013.01); A61B 5/4839 (2013.01); A61B 5/743 (2013.01); A61B 2562/12 (2013.01); A61F 2013/0097 (2013.01);
Abstract

Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing. The dressing can be therapeutic. The dressing includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions. The matrix is at least partially permeable to the analyte. The device emits a detectable signal when the sensor is excited in the presence of the analyte. In one version of the dressing, the sensor includes a meso-unsubstituted metallated porphyrin that is sensitive towards oxygen. The metallated porphyrin can be excited when illuminated at a first wavelength, followed by emission of phosphorescence at a second wavelength whose intensity can be used as an indicator for oxygen concentration.


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