The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 13, 2024
Filed:
Aug. 11, 2021
Applicant:
Boehringer Ingelheim International Gmbh, Ingelheim am Rhein, DE;
Inventors:
Jana Podhorna, Wiesbaden, DE;
Holger Rosenbrock, Mittelbiberach, DE;
Sun Young Yum, Seoul, KR;
Yihua Zhao, Bedford, NY (US);
Assignee:
Boehringer Ingelheim International GmbH, Ingelheim am Rhein, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/422 (2006.01); A61P 25/18 (2006.01); A61P 25/28 (2006.01);
U.S. Cl.
CPC ...
A61K 31/422 (2013.01); A61P 25/18 (2018.01); A61P 25/28 (2018.01);
Abstract
The invention relates to the treatment of cognitive impairment associated with schizophrenia (CIAS) with a specific GlyT1 inhibitor ([5-(methylsulfonyl)-2-{[(2R)-1,1,1-trifluoropropan-2-yl]oxy}phenyl]{(1R,5R)-1-[5-(trifluoromethyl)-1,2-oxazol-3-yl]-3-azabicyclo[3.1.0]hex-3-yl}methanone). A 12-week treatment in a phase 2 study showed improvement in cognitive function as measured by the MATRICS Consensus Cognitive Battery (MCCB) overall composite score.