The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 06, 2024

Filed:

Oct. 12, 2021
Applicants:

Commonwealth Scientific and Industrial Research Organisation, Australian Capital Territory, AU;

University of Georgia Research Foundation, Inc., Athens, GA (US);

Inventors:

Andrew Bean, Ocean Grove, AU;

John William Lowenthal, Belmont, AU;

Luis Fernando Malaver-Ortega, Glen Waverly, AU;

Ralph A. Tripp, Watkinsville, GA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 7/00 (2006.01); A61K 39/12 (2006.01); A61K 39/145 (2006.01); A61K 39/155 (2006.01); A61K 39/17 (2006.01); C12N 7/02 (2006.01);
U.S. Cl.
CPC ...
C12N 7/02 (2013.01); A61K 39/12 (2013.01); A61K 39/145 (2013.01); A61K 39/17 (2013.01); C12N 7/00 (2013.01); C12N 2760/16051 (2013.01); C12N 2760/16052 (2013.01); C12N 2760/16134 (2013.01); C12N 2760/16151 (2013.01); C12N 2760/16152 (2013.01); C12N 2760/16234 (2013.01); C12N 2760/16334 (2013.01); C12N 2760/18251 (2013.01);
Abstract

The present invention relates to methods of replicating viruses in vitro. In particular, the invention relates to a genetically modified population of cells, and/or a population of cells treated with an exogenous compound, wherein the cells are capable of producing more virus than cells lacking the genetic modification and/or lacking treatment with the exogenous compound. The invention also relates to methods of producing populations of such cells, as well as the use of the viruses obtained to prepare vaccine compositions.


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