The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 06, 2024
Filed:
Aug. 07, 2020
Public University Corporation Nagoya City University, Nagoya, JP;
Fujifilm Corporation, Tokyo, JP;
Tamihide Matsunaga, Nagoya, JP;
Takahiro Iwao, Nagoya, JP;
Tomoki Kabeya, Nagoya, JP;
Shinji Mima, Kanagawa, JP;
Toshihide Miyashita, Kanagawa, JP;
PUBLIC UNIVERSITY CORPORATION NAGOYA CITY UNIVERSITY, Nagoya, JP;
FUJIFILM Corporation, Tokyo, JP;
Abstract
An object of the present invention is to provide a new means capable of easily and efficiently preparing cells showing a function more similar to the function of intestinal epithelial cells of a living body. According to the present invention, pluripotent stem cells are induced to differentiate into intestinal stem cell-like cells by a method for inducing differentiation of pluripotent stem cells into intestinal epithelial cells, the method including a step (1) of differentiating pluripotent stem, cells into intestinal stem cell-like cells and a step (2) of differentiating the intestinal stem cell-like cells obtained in the step (1) into intestinal epithelial cell-like cells by using an MEK1 inhibitor, a DNA methylation inhibitor, a TGFβ receptor inhibitor, EGF, and a cAMP activator in combination.