The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 06, 2024
Filed:
Apr. 10, 2019
Applicants:
President and Fellows of Harvard College, Cambridge, MA (US);
The General Hospital Corporation, Boston, MA (US);
Inventors:
Casey A. Maguire, Arlington, MA (US);
David P. Corey, Cambridge, MA (US);
Bence Gyorgy, Cambridge, MA (US);
Assignees:
President and Fellows of Harvard College, Cambridge, MA (US);
The General Hospital Corporation, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/70 (2006.01); A61K 9/00 (2006.01); A61K 48/00 (2006.01); C07K 14/05 (2006.01); C07K 14/705 (2006.01); C12N 7/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/70 (2013.01); A61K 9/0019 (2013.01); A61K 9/0046 (2013.01); A61K 48/0008 (2013.01); C07K 14/705 (2013.01); C12N 7/00 (2013.01); A61K 38/00 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14151 (2013.01);
Abstract
Aspects of the disclosure relate to compositions and methods useful for treating hereditary hearing loss, for example, Usher syndrome type 3A or nonsyndromic hearing loss and deafness (DFNB1). In some embodiments, the disclosure provides isolated nucleic acids, vectors, and rAAV.9.PHP.B comprising a transgene encoding a Clarin-1 or a GJB2, and methods of treating hearing loss using the same.