The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 06, 2024
Filed:
Apr. 10, 2019
Wuxi Biologics (Shanghai) Co., Ltd., Pudong New District, CN;
Wuxi Biologics Ireland Limited, Dublin, IE;
Open Monoclonal Technology, Inc., San Diego, CA (US);
WUXI BIOLOGICS (SHANGHAI) CO., LTD., Shanghai, CN;
WUXI BIOLOGICS IRELAND LIMITED, Dublin, IE;
OPEN MONOCLONAL TECHNOLOGY, INC., San Diego, CA (US);
Abstract
Provided are novel fully human monoclonal antibodies that bind to human 4-1BB. It also provides the methods of hybridoma generation using humanized rats, the nucleic acid molecules encoding the anti-4-1BB antibodies, vectors and host cells used for the expression of anti-4-1BB antibodies. The invention further provides methods for validating the function of antibodies in vitro and the efficacy of antibodies in vivo. The antibodies of invention provide a very potent agent for the treatment of multiple cancers via modulating human immune function.