The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 06, 2024
Filed:
Apr. 21, 2023
Applicant:
Biomadison, Inc, Del Mar, CA (US);
Inventors:
Ward C Tucker, Monona, WI (US);
Francis Mark Dunning, Madison, WI (US);
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/00 (2006.01); C12N 9/52 (2006.01); C12Q 1/37 (2006.01); G01N 33/542 (2006.01);
U.S. Cl.
CPC ...
C07K 14/00 (2013.01); C12N 9/52 (2013.01); C12Q 1/37 (2013.01); G01N 33/542 (2013.01); G01N 2333/33 (2013.01);
Abstract
Recombinant nucleic acids encoding reporting constructs for characterizingneurotoxin protease activity and cells that incorporate such recombinant nucleic acids and that are suitable for use in cell-based assays for the neurotoxin are provided. The encoded reporting constructs are a pair of recombinant hybrid proteins that act in concert. The reporting constructs are a pair of recombinant hybrid proteins that act in concert, and that include aneurotoxin protease recognition and cleavage sequence positioned to release a fluorophore upon cleavage.