The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 06, 2024
Filed:
Dec. 21, 2020
Applicant:
Translate Bio, Inc., Lexington, MA (US);
Inventors:
Shrirang Karve, Lexington, MA (US);
Frank DeRosa, Lexington, MA (US);
Ashish Sarode, Lexington, MA (US);
Natalia Vargas Montoya, Lexington, MA (US);
Priyal Patel, Lexington, MA (US);
Assignee:
TRANSLATE BIO, INC., Waltham, MA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/51 (2006.01); A61K 31/7105 (2006.01); B82Y 5/00 (2011.01); B82Y 40/00 (2011.01);
U.S. Cl.
CPC ...
A61K 9/5192 (2013.01); A61K 31/7105 (2013.01); B82Y 5/00 (2013.01); B82Y 40/00 (2013.01);
Abstract
The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of combining a solution of preformed lipid nanoparticles with lipid nanoparticles encapsulating mRNA, resulting in a composition of increased potency of mRNA encoded protein expression in vivo.