The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 06, 2024
Filed:
Apr. 10, 2020
Applicant:
Zielbio, Inc., Charlottesville, VA (US);
Inventor:
Kimberly A. Kelly, Goochland, VA (US);
Assignee:
ZielBio, Inc., Charlottesville, VA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 31/282 (2006.01); A61K 31/519 (2006.01); A61K 31/7068 (2006.01); A61K 47/65 (2017.01); A61K 47/68 (2017.01); A61P 35/00 (2006.01); C07K 16/18 (2006.01); C07K 16/30 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6803 (2017.08); A61K 31/282 (2013.01); A61K 31/519 (2013.01); A61K 31/7068 (2013.01); A61K 47/65 (2017.08); A61P 35/00 (2018.01); C07K 16/18 (2013.01); C07K 16/30 (2013.01); C07K 16/303 (2013.01); C07K 2317/73 (2013.01); C07K 2317/92 (2013.01);
Abstract
Aspects of the disclosure provide compositions and methods for treating cancer characterized by surface expression of plectin-1. The disclosure relates, in part, to combinations of therapeutic agents (e.g., anti-plectin-1 antibodies and certain small molecules) that function together (e.g., synergistically) to inhibit cancer cell growth. In some embodiments, the disclosure relates to anti-plectin-1 antibody-drug-conjugates (ADCs).