The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 06, 2024
Filed:
Jan. 28, 2022
Applicant:
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);
Inventors:
Xuejun Chen, Clarksburg, MD (US);
Jeffrey Boyington, Clarksburg, MD (US);
Hongying Duan Holdsworth, McLean, VA (US);
Cheng Cheng, Bethesda, MD (US);
John R. Mascola, Rockville, MD (US);
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/21 (2006.01); C07K 14/005 (2006.01); C07K 14/16 (2006.01); C12N 7/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/21 (2013.01); C07K 14/005 (2013.01); C07K 14/162 (2013.01); C12N 7/00 (2013.01); C12Y 205/01078 (2013.01); A61K 2039/5258 (2013.01); A61K 2039/55555 (2013.01); C07K 2319/00 (2013.01); C12N 2740/16023 (2013.01); C12N 2740/16043 (2013.01); C12N 2740/16111 (2013.01); C12N 2740/16122 (2013.01); C12N 2740/16134 (2013.01); C12N 2740/16171 (2013.01);
Abstract
Embodiments of immunogens based on the outer domain of HIV-1 gp120 and methods of their use and production are disclosed. Nucleic acid molecules encoding the immunogens are also provided. In several embodiments, the immunogens can be used to prime an immune response to gp120 in a subject, for example, to treat or prevent an HIV-1 infection in the subject.