The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 06, 2024

Filed:

Jun. 16, 2020
Applicant:

Board OR Regents, the University of Texas System, Austin, TX (US);

Inventors:

Tonyia Eaves-Pyles, Galveston, TX (US);

Richard B. Pyles, Galveston, TX (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61K 38/57 (2006.01); A61K 47/60 (2017.01); A61P 1/00 (2006.01); A61P 29/00 (2006.01); A61P 31/04 (2006.01); A61P 37/02 (2006.01); C07K 14/81 (2006.01);
U.S. Cl.
CPC ...
A61K 38/57 (2013.01); A61K 47/60 (2017.08); A61P 1/00 (2018.01); A61P 29/00 (2018.01); A61P 31/04 (2018.01); A61P 37/02 (2018.01); C07K 14/8139 (2013.01);
Abstract

The present invention includes a composition and method of modulating a dysregulated gut-derived inflammation following a thermal injury comprising: identifying a mammal in need of treatment for the dysregulated gut-derived inflammation following the thermal injury; and providing the mammal with a recombinant Cystatin 9 (CST9) and Cystatin C (CSTC) in a synergistic amount sufficient to restrain or prevent a life-threatening, unrestrained systemic dysregulated gut-derived inflammation in the mammal caused by the thermal injury.


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