The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 06, 2024
Filed:
Jan. 28, 2021
Bayer Pharma Aktiengesellschaft, Berlin, DE;
The Broad Institute, Inc., Cambridge, MA (US);
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Timothy A. Lewis, Marlborough, MA (US);
Alex Burgin, Boston, MA (US);
Monica Schenone, Chestnut Hill, MA (US);
Xiaoyun Wu, Winchester, MA (US);
Heidi Greulich, Arlington, MA (US);
Matthew Meyerson, Concord, MA (US);
Luc De Waal, Medford, MA (US);
Antje Margret Wengner, Berlin, DE;
Knut Eis, Berlin, DE;
Philip Lienau, Berlin, DE;
Ulrike Sack, Berlin, DE;
Martin Lange, Berlin, DE;
Bayer Pharma Aktiengesellschaft, Berlin, DE;
The Broad Institute, Inc., Cambridge, MA (US);
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
Abstract
The present invention features improved compounds, especially methods of identifying patients having cancer using biomarkers (e.g., PDE3A, SLFN12 and/or CREB3L1) that correlate with drug sensitivity and consequently treating a stratified patient population with an agent of the invention (e.g., Compounds 1-6 disclosed herein).