The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 30, 2024
Filed:
Sep. 22, 2022
Santa Clara University, Santa Clara, CA (US);
University of South Florida, Tampa, FL (US);
The Regents of the University of California, Oakland, CA (US);
Mustafa Hajij, Santa Clara, CA (US);
Ghada Alzamzmi, Rockville, MD (US);
Nina Miolane, Santa Barbara, CA (US);
Santa Clara University, Santa Clara, CA (US);
The Regents of the University of California, Oakland, CA (US);
University of South Florida, Tampa, FL (US);
Abstract
A method for predicting side effects of a combination of drugs administered concurrently includes training a multi-modal cell complex neural network (MCXN) on a dataset. The MCXN includes nodes representing the drugs and proteins, pair-wise relationships between nodes representing interactions between pairs of drugs and/or proteins, and k-wise relationships between the nodes representing interactions between k drugs and/or proteins, where k¿2. The training dataset includes a list of drugs, a list of proteins, and pharmacological information about the drugs in the list of drugs and proteins in the list of proteins. A specification of the combination of at least three drugs to be administered concurrently is input to the MCXN which predicts probabilities that administering the combination of drugs concurrently results in potential side effects. It also predicts both frequencies of the potential side effects and severities of the potential side effects.