The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 30, 2024
Filed:
Apr. 17, 2019
The Regents of the University of Michigan, Ann Arbor, MI (US);
Nara Institute of Science and Technology, Ikoma, JP;
Ayyalusamy Ramamoorthy, Ann Arbor, MI (US);
Thirupathi Ravula, Ann Arbor, MI (US);
Bikash Sahoo, Ann Arbor, MI (US);
Kazuma Yasuhara, Ikoma, JP;
Jin Arakida, Ikoma, JP;
Jun-Ichi Kikuchi, Ikoma, JP;
Nara Institute of Science and Technology, Ikoma, JP;
THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US);
Abstract
The disclosure generally relates generally to lipid nanodiscs, in particular to lipid nanodiscs formed from acryloyl-based copolymers. A lipid nanodisc according to the disclosure includes a lipid bilayer having a first hydrophilic face and a second hydrophilic face opposing the first hydrophilic face, and a hydrophobic edge between the opposing hydrophilic faces, and an acryloyl-based copolymer encircling the hydrophobic edge of the lipid bilayer. The acryloyl-based copolymer includes a first monomer unit having a pendant hydrophobic group and a second monomer unit having a pendant hydrophilic group. Methods of making and characterizing the lipid nanodiscs are also disclosed.