The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 30, 2024
Filed:
Sep. 19, 2018
Applicants:
The University of British Columbia, Vancouver, CA;
Cdrd Ventures Inc., Vancouver, CA;
Inventors:
Megan Levings, Vancouver, CA;
Paul Orban, Vancouver, CA;
Nicholas Dawson, Vancouver, CA;
Caroline Lamarche, Vancouver, CA;
Jan Peter Bergqvist, Vancouver, CA;
Assignees:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 35/17 (2015.01); A61P 37/06 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2833 (2013.01); A61K 35/17 (2013.01); A61P 37/06 (2018.01); C07K 14/7051 (2013.01); C07K 14/70517 (2013.01); C07K 14/70521 (2013.01); C07K 14/70578 (2013.01); C07K 2317/24 (2013.01); C07K 2317/33 (2013.01); C07K 2317/622 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01);
Abstract
Provided are humanized anti-HLA-A2 antibodies. In certain aspects, the humanized anti-HLA-A2 antibodies are capable of constituting an antigen binding domain of a chimeric antigen receptor (CAR), where the CAR is capable of being expressed in a human cell such that the CAR specifically binds to HLA-A2. Also provided are CARs that include the humanized anti-HLA-A2 antibodies. Modified cells including the antibodies and CARs, as well as methods of using such modified cells are also provided.