The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 30, 2024
Filed:
Sep. 06, 2018
Applicant:
Gracell Biotechnologies (Shanghai) Co., Ltd., Shanghai, CN;
Inventors:
Xinxin Wang, Shanghai, CN;
Zhongdong Shi, Shanghai, CN;
Liping Liu, Shanghai, CN;
Chunhui Yang, Shanghai, CN;
Jing Sun, Shanghai, CN;
Songbai Cai, Shanghai, CN;
Wei Cao, Shanghai, CN;
Assignee:
GRACELL BIOTECHNOLOGIES (SHANGHAI) CO., LTD., Shanghai, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/725 (2006.01); C07K 16/28 (2006.01); C12N 5/0783 (2010.01);
U.S. Cl.
CPC ...
C07K 14/7051 (2013.01); C07K 16/2803 (2013.01); C12N 5/0636 (2013.01); C07K 2317/53 (2013.01); C07K 2317/622 (2013.01); C07K 2319/03 (2013.01); C12N 2310/20 (2017.05); C12N 2510/00 (2013.01);
Abstract
Provided are a universal chimeric antigen receptor (CAR) T cell and preparation method and application thereof. The binding of the cell HLA-A/HLA-B to the TCR is inhibited; the TCR gene expression is silenced; the invention may be used for allogeneic tumor treatment and does not cause GVHD and HVG reaction during allogeneic infusion, and thus improves the survival and antineoplastic effect of allogeneic CAR-T cells in the recipient.