logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12049487 B1

PDFFull Text
Date of Patent:
Jul. 30, 2024

Filed:

Sep. 06, 2018

Universal chimeric antigen receptor t-cell preparation technique

Applicant:

Gracell Biotechnologies (Shanghai) Co., Ltd., Shanghai, CN;

Inventors:

Xinxin Wang, Shanghai, CN;

Zhongdong Shi, Shanghai, CN;

Liping Liu, Shanghai, CN;

Chunhui Yang, Shanghai, CN;

Jing Sun, Shanghai, CN;

Songbai Cai, Shanghai, CN;

Wei Cao, Shanghai, CN;

Assignee:

GRACELL BIOTECHNOLOGIES (SHANGHAI) CO., LTD., Shanghai, CN;

Attorney:

Michael Best & Friedrich LLP

Primary Examiner:

Jessica H Roark

Int. Cl.
CPC ...
C07K 14/725 (2006.01); C07K 16/28 (2006.01); C12N 5/0783 (2010.01);
U.S. Cl.
CPC ...
C07K 14/7051 (2013.01); C07K 16/2803 (2013.01); C12N 5/0636 (2013.01); C07K 2317/53 (2013.01); C07K 2317/622 (2013.01); C07K 2319/03 (2013.01); C12N 2310/20 (2017.05); C12N 2510/00 (2013.01);
Abstract

Provided are a universal chimeric antigen receptor (CAR) T cell and preparation method and application thereof. The binding of the cell HLA-A/HLA-B to the TCR is inhibited; the TCR gene expression is silenced; the invention may be used for allogeneic tumor treatment and does not cause GVHD and HVG reaction during allogeneic infusion, and thus improves the survival and antineoplastic effect of allogeneic CAR-T cells in the recipient.

Find Patent Forward Citations

Wang, Xinxin. (2024). Universal chimeric antigen receptor t-cell preparation technique (U.S. Patent No. 12049487). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12049487

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

Loading…