The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 30, 2024
Filed:
Oct. 01, 2016
Applicant:
Whitehead Institute for Biomedical Research, Cambridge, MA (US);
Inventors:
Mohammad Rashidian, Cambridge, MA (US);
Hidde L. Ploegh, Jamaica Plain, MA (US);
Assignee:
Whitehead Institute for Biomedical Research, Cambridge, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 51/00 (2006.01); A61K 51/10 (2006.01); A61M 36/14 (2006.01); A61P 35/00 (2006.01); C07K 16/24 (2006.01); C07K 16/28 (2006.01); C12P 21/00 (2006.01); G01N 33/58 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 51/1093 (2013.01); A61K 51/1021 (2013.01); A61K 51/1027 (2013.01); A61P 35/00 (2018.01); C07K 16/247 (2013.01); C07K 16/2833 (2013.01); C07K 16/2845 (2013.01); C12P 21/00 (2013.01); C12Y 304/22 (2013.01); G01N 33/58 (2013.01); A61K 2039/505 (2013.01); C07K 2317/22 (2013.01); C07K 2317/35 (2013.01); C07K 2317/569 (2013.01);
Abstract
Provided herein are methods for producing site specific PEG modifications to single domain antibodies (e.g., VHHs). Methods for producing site-specifically conjugated bivalent single domain antibodies (e.g., VHHs) are also provided. Methods for labeling (e.g., with a fluorophore or radionuclide) site-specifically PEGylated single domain antibodies and site-specifically conjugated bivalent single domain antibodies are also provided.