The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 30, 2024

Filed:

Jan. 04, 2019
Applicants:

Institut National DE LA Sante ET DE LA Recherche Medicale (Inserm), Paris, FR;

Centre National DE LA Recherche Scientifique, Paris, FR;

Université Côte D'azur, Nice, FR;

Inventors:

Thierry Passeron, Nice, FR;

Rachid Benhida, Nice, FR;

Pascal Dao, Nice, FR;

Gian Marco De Donatis, Nice, FR;

Anthony Martin, Nice, FR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4706 (2006.01); A61K 39/395 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); A61P 35/04 (2006.01); C07D 215/44 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4706 (2013.01); A61K 39/3955 (2013.01); A61P 35/00 (2018.01); A61P 35/04 (2018.01); C07D 215/44 (2013.01); A61K 45/06 (2013.01); C07K 16/2818 (2013.01); C07K 16/2827 (2013.01);
Abstract

The present invention relates to a compound of general formula (I), wherein Ris OCHCHOCHor OCH, R'is H or OH, Ris Cl, F, Br or I, with the proviso that when: Ris OCHCHOCHthen R′is H, Ris OCHthen R′is OH, its pharmaceutically acceptable salts and/or optical isomers, tautomers, solvates or isotopic variations thereof. The invention also relates to said compounds for use in the treatment of cancer, namely solid tumor cancer, and preferably those selected from melanoma, colon, lung, pancreas, kidney, Merkel carcinoma, squamous cell carcinoma, prostate, breast and bladder. The invention also relates to a pharmaceutical composition comprising said compounds.


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