The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 23, 2024
Filed:
Feb. 28, 2020
Applicant:
Allogene Therapeutics, Inc., South San Francisco, CA (US);
Inventors:
Regina Junhui Lin, San Mateo, CA (US);
Thomas John Van Blarcom, Oakland, CA (US);
Siler Panowski, Berkeley, CA (US);
Barbra Johnson Sasu, San Francisco, CA (US);
Assignee:
Allogene Therapeutics, Inc., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/715 (2006.01); A61K 35/17 (2015.01); A61K 39/00 (2006.01); A61P 35/00 (2006.01); C07K 16/40 (2006.01); C12N 5/0783 (2010.01); C12N 7/00 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
C07K 14/715 (2013.01); A61K 35/17 (2013.01); A61P 35/00 (2018.01); C07K 16/40 (2013.01); C12N 5/0636 (2013.01); C12N 7/00 (2013.01); C12N 15/86 (2013.01); C07K 2317/24 (2013.01); C07K 2317/73 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/30 (2013.01); C07K 2319/33 (2013.01); C12N 2740/15043 (2013.01);
Abstract
Provided herein are constitutively active chimeric cytokine receptors (CACCRs). When present on chimeric antigen receptor (CAR)-bearing immune cells, such CACCRs allow for increased immune cell activation, proliferation, persistence, and/or potency. Also provided are methods of making and using the CACCRs described herein.