The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 23, 2024
Filed:
Apr. 21, 2021
Applicant:
Hoffmann-la Roche Inc., Little Falls, NJ (US);
Inventors:
Joerg Lill, Aarau, CH;
Filippo Sladojevich, Rheinfelden, CH;
Assignee:
GENENTECH, INC., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 1/06 (2006.01); B01D 69/02 (2006.01); C07H 21/00 (2006.01);
U.S. Cl.
CPC ...
C07H 1/06 (2013.01); B01D 69/02 (2013.01); C07H 21/00 (2013.01); B01D 2325/20 (2013.01);
Abstract
The invention relates to a new process for the purification of oligonucleotides which comprises the removal of the acid labile 5'hydroxy protecting group at the 5′-O-oligonucleotide terminus of the oligonucleotide by way of tangential flow filtration with an acidic buffer solution. The process requires less steps and allows a higher degree of automation.