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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12043612 B1

PDFFull Text
Date of Patent:
Jul. 23, 2024

Filed:

May. 06, 2021

Methods of manufacturing a bifunctional compound, ultrapure forms of the bifunctional compound, and dosage forms comprising the same

Applicant:

Arvinas Operations, Inc., New Haven, CT (US);

Inventors:

Laura E. N. Allan, Dalkeith, GB;

Chungpin Herman Chen, Madison, CT (US);

Hanqing Dong, Madison, CT (US);

John A. Grosso, Princeton Jct., NJ (US);

Royal J. Haskell, III, Durham, CT (US);

Rhys LLoyd, North Lanarkshire, GB;

Hayley Reece, Dalkeith, GB;

Assignee:

Arvinas Operations, Inc., New Haven, CT (US);

Attorney:

COOLEY LLP

Primary Examiner:

Bahar Craigo

Assistant Examiner:

Manahil Mirghani Ali Abdalhameed

Int. Cl.
CPC ...
C07D 401/14 (2006.01); A61K 9/00 (2006.01); A61K 9/20 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); A61K 9/0053 (2013.01); A61K 9/2009 (2013.01); A61K 9/2018 (2013.01); A61K 9/2054 (2013.01); A61K 45/06 (2013.01); C07B 2200/13 (2013.01);
Abstract

The present disclosure relates to ultra-pure forms, polymorphs, amorphous forms, and formulations of N-[(1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-[4-({4-[2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]piperazin-1-yl}methyl)piperidin-1-yl]pyridazine-3-carboxamide, referred to herein as Compound A: The present disclosure also relates methods of manufacturing and purifying the same, as well as intermediates useful in the synthesis of Compound A. The ultra-pure forms, polymorphs, amorphous forms, and formulations of Compound A can be used as therapeutic agents for the treatment of various diseases and conditions such as cancer.

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Allan, Laura E. N.. (2024). Methods of manufacturing a bifunctional compound, ultrapure forms of the bifunctional compound, and dosage forms comprising the same (U.S. Patent No. 12043612). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12043612

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