The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 23, 2024
Filed:
May. 11, 2018
Icahn School of Medicine AT Mount Sinai, New York, NY (US);
Memorial Sloan Kettering Cancer Center, New York, NY (US);
Peter Palese, New York, NY (US);
Adolfo Garcia-Sastre, New York, NY (US);
Dmitriy Zamarin, New York, NY (US);
Jedd D. Wolchok, New York, NY (US);
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, New York, NY (US);
MEMORIAL SLOAN KETTERING CANCER CENTER, New York, NY (US);
Abstract
Described herein are chimeric Newcastle disease viruses comprising a packaged genome comprising a transgene encoding interleukin-12. The chimeric Newcastle disease viruses and compositions thereof are useful in combination with an antagonist of programmed cell death protein 1 ('PD-1') or a ligand thereof in the treatment of cancer. In particular, described herein are methods for treating cancer comprising administering the chimeric Newcastle disease viruses in combination with an antagonist of PD-1 or a ligand thereof, wherein the chimeric Newcastle disease virus comprises a packaged genome comprising a transgene encoding interleukin-12.