The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 23, 2024
Filed:
Jul. 17, 2023
Applicant:
Arcutis Biotherapeutics, Inc., Westlake Village, CA (US);
Inventor:
David W. Osborne, Fort Collins, CO (US);
Assignee:
ARCUTIS BIOTHERAPEUTICS, INC., Westlake Village, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/44 (2006.01); A61K 9/00 (2006.01); A61K 9/06 (2006.01); A61K 9/12 (2006.01); A61K 45/06 (2006.01); A61K 47/10 (2017.01); A61K 47/24 (2006.01);
U.S. Cl.
CPC ...
A61K 31/44 (2013.01); A61K 9/0014 (2013.01); A61K 9/06 (2013.01); A61K 9/122 (2013.01); A61K 47/10 (2013.01); A61K 47/24 (2013.01); A61K 45/06 (2013.01);
Abstract
A method for altering the PK profile of a pharmaceutical formulation containing a PDE-4 inhibitor, such as roflumilast, to reduce the spike in Cmax. The spike in Cmax is reduced by topically administering the PDE-4 inhibitor in combination with one or more phosphate ester surfactants. Reducing the spike in Cmax will reduce gastrointestinal side effects and result in better patient compliance.