The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 16, 2024
Filed:
Jul. 02, 2019
Applicant:
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Inventors:
Mark A. Huffman, Warren, NJ (US);
Anna Fryszkowska, New York, NY (US);
Joshua N. Kolev, Califon, NJ (US);
Paul N. Devine, Tinton Falls, NJ (US);
Kevin R. Campos, Berkeley Heights, NJ (US);
Matthew Truppo, Princeton, NJ (US);
Christopher C. Nawrat, Garwood, NJ (US);
Assignee:
Merck, Sharp & Dohme LLC, Rahway, NJ (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12P 19/40 (2006.01); C07C 33/042 (2006.01); C07F 9/113 (2006.01); C07H 13/00 (2006.01); C12P 7/18 (2006.01); C12P 9/00 (2006.01); C12P 17/04 (2006.01);
U.S. Cl.
CPC ...
C12P 19/40 (2013.01); C07C 33/042 (2013.01); C07F 9/113 (2013.01); C07H 13/00 (2013.01); C12P 7/18 (2013.01); C12P 9/00 (2013.01); C12P 17/04 (2013.01);
Abstract
The present invention relates to an enzymatic synthesis of 4'-ethynyl-2′-deoxy nucleosides and analogs thereof, for example EFdA, that eliminates the use of protecting groups on the intermediates, improves the stereoselectivity of glycosylation and reduces the number of process steps needed to make said compounds. It also relates to the novel intermediates employed in the process.