The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 16, 2024
Filed:
Apr. 18, 2018
Applicants:
The University of Tokyo, Tokyo, JP;
Npt Co., Ltd., Tokyo, JP;
Inventors:
Yang Jia, Tokyo, JP;
Shohei Miyamoto, Tokyo, JP;
Kenichiro Hara, Fukuoka, JP;
Atsuhumi Iwanaga, Fukuoka, JP;
Kenzaburo Tani, Tokyo, JP;
Assignees:
THE UNIVERSITY OF TOKYO, Tokyo, JP;
NPT CO., LTD., Tokyo, JP;
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 7/00 (2006.01); A61K 9/00 (2006.01); A61K 35/76 (2015.01); A61P 35/00 (2006.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
C12N 7/00 (2013.01); A61K 9/0014 (2013.01); A61K 35/76 (2013.01); A61P 35/00 (2018.01); C12N 15/11 (2013.01); C12N 15/1131 (2013.01); C12N 15/1135 (2013.01); C12N 2310/141 (2013.01); C12N 2770/32321 (2013.01); C12N 2770/32333 (2013.01);
Abstract
A gene-modified coxsackievirus that is to be used in oncolytic virotherapy and is improved in safety and/or aggressiveness is provided. A gene-modified coxsackievirus that contains a mutated genome with a coxsackievirus B3 wild-type (CVB3-WT) genome inserted with at least one polynucleotide constituted of a target sequence for at least one of either of miR-34a and miR-34c and is suppressed in proliferation in normal cells is provided.